Novel synthetic chalcone‐coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection
نویسندگان
چکیده
منابع مشابه
Neuroprotection and anxiety like behavior reduction of Allium hirtifolium and Astragalus hamosus in the Aβ-injected rat
Background and objectives:Traditional medicine is an important approach to achieve new therapeutic strategies in basic and clinical pharmacology. Allium hirtifolium Boiss. and Astragalus hamosus L. have been mentioned in Iranian Traditional Medicine references for a kind of dementia with features and symptoms similar to those of Alzheimer's disease (AD). In th...
متن کاملneuroprotection and anxiety like behavior reduction of allium hirtifolium and astragalus hamosus in the aβ-injected rat
background and objectives:traditional medicine is an important approach to achieve new therapeutic strategies in basic and clinical pharmacology. allium hirtifolium boiss. and astragalus hamosus l. have been mentioned in iranian traditional medicine references for a kind of dementia with features and symptoms similar to those of alzheimer's disease (ad). in the present study, the neuroprot...
متن کاملAn effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.
Passive immunization against β-amyloid (Aβ) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD). However, traditional passive immunization approaches carry the risk of Fcγ receptor-mediated overactivation of microglial cells, which may contribute to an inappropriate proinflammatory response leading to vasogenic edema and cerebral microhemorrhage...
متن کاملNeuroprotection and anxiety like behavior reduction of Allium hirtifolium and Astragalus hamosus in the Aβ-injected rat
Background and objectives: Traditional medicine is an important approach to achieve new therapeutic strategies in basic and clinical pharmacology. Allium hirtifolium Boiss. and Astragalus hamosus L. have been mentioned in Iranian Traditional Medicine references for a kind of dementia with features and symptoms similar to those of Alzheimer's disease (AD). In the present study, the neuroprotecti...
متن کاملNovel mitochondrial targets for neuroprotection.
Mitochondrial dysfunction contributes to the pathophysiology of acute neurologic disorders and neurodegenerative diseases. Bioenergetic failure is the primary cause of acute neuronal necrosis, and involves excitotoxicity-associated mitochondrial Ca(2+) overload, resulting in opening of the inner membrane permeability transition pore and inhibition of oxidative phosphorylation. Mitochondrial ene...
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ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2018
ISSN: 1755-5930,1755-5949
DOI: 10.1111/cns.13058